Qualitative & Semi - Quantitative Positive, negative, cut off
Sample
10 ul serum
Specificity
97.90%
Sensitivity
98.90%
Total Time
~60 min
Shelf Life
12 Months from the manufacturing date
Description
MPO ELISA Test kit
MPO ELISA Test kit Intended Use
Myeloperoxidase (MPO) Elisa test kit is intended for the qualitative and semi-quantitative detection of IgG-class antibody to myeloperoxidase in human serum. The result from MPO elisa test can be used as an aid in the diagnosis of various autoimmune vasculitic disorders characterized by elevated levels of anti-neutrophil cytoplasmic antibodies (ANCA). MPO-ANCA may be associated with autoimmune disorders such as Wegener’s granulomatosis, ICGN, MPA and PRS.
Method Principle
This Diagnostic Automation/ Cortez Diagnostics Inc. Human Myeloperoxidase (MPO) ELISA test kit is designed to detect IgG class antibodies to MPO in human sera. Wells of microplate are sensitized by passive absorption with MPO antigen. The test procedure involves three incubation steps. For further details please refer to complete instructions manual supplied with the product.
Background Information
Since the initial discovery of Anti-neutrophil cytoplasmic antibody (ANCA), scientists have associated ANCA with a number of Systemic Vasculitides (SV). ANCA includes two primary specificities: C-ANCA directed against Proteinase-3 (PR-3), and P-ANCA directed against Myeloperoxidase (MPO). Testing for both P-ANCA and C-ANCA is highly recommended in the laboratory workup of patients who present with clinical features suggestive of SV. The clinical syndromes most frequently associated with ANCA are as follows: Wegener’s granulomatosis, Polyarteritis, “Overlap” Vasculitis, Idiopathic Crescentic Glomerulonephritis (ICGN), and Kawasaki Disease.
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